Dealing With Headaches

It’s a beautiful day in the Pain-er-hood
A beautiful day for a neighbor… Howdy, neighbor! Hope you are having a great day. No? You say your life sucks because of acute migraines, which really aren’t so cute? Well, follow me to the Land of Make Believe, otherwise known as the wacky world of Phase I Clinical Test trials for new drugs, where anything can happen and usually does.

Can You Say ‘Transdermal’? Sure You Can!

One of the suppossed breakthroughs in modern medicine is the creation of the transdermal patch. That’s one of those white bandage doo-hickeys you tape to your body and then absorb the medicine bit by bit through your skin. This really isn’t much different than the medicinal poltices or herbal compresses native healers have used for thousands of years. However, it wasn’t hip until the success (read=lots of money made) on the nicotene patch.

Why am I not keen on transdermal patches? Because I have realtives who can’t have them because for some strange reason their bodies soak up all of the goodies in the patch IMMEDIATELY. This has lead to some very sick relatives. However, those that used the nictoene patch when they tried to quit smoking were pretty happy until they found out why they were so happy.

The Latest Future Star

NP101 is the trail name of the transdermal patch for acute migraines that has done well so far. It is put out by NuPathe, Inc, a very small pharmaceutical company reported to be “privately held” (sounds painful.) The patch is a combination of sumatriptan (the active medicine in Imitrex) and “NuPathe’s SmartRelief™ proprietary iontophoretic transdermal technology”. (No, I don’t know what that means, either, but it sure sounds impressive, doesn’t it?)

The Nitty Gritty

NP101 was tested against Imitrex nose spray, tablet and injections. There were 23 human guinea pigs descibed as “healthy”. I assume that means the subjects were not prone to migraines if they were “healthy” and that the migraines were chemically induced. I could not find details of that fact on the Internet or in NuPathe’s press release.

The big hope is that the patch can give you the same relief as with triptans, but without the wacky side effects. It didn’t give any serious side-effects to the 23 volunteers except swelling of the skin at the patch site. Although some reports say this patch will be availbale in a year, odds are with the way Phase II and Phase III Trials have gone for other drugs recently, that it will be at least two years.

Whoops. That’s all the time we have for this episode, boys and girls. Time to go back to real world where all your dreams are clouded by a haze of blinding migraine pain and splintering dry heaves. Bye for now!