Injectable Valproate For Migraines Looking Good
Monday, March 24th, 2008
This is good news or bad news, depending on how much you like needles. Researchers in Greece and England have released promising results about an injectable medicine for migraines called sodium valproate (also known as valproic acid). It is thought that vaproate sodium reduces electrical activity in the brain, which may be a cause of migraines.
The Causes of Migraines
We actually don’t know what causes migraines. There have been many theories put forth from constricted blood vessels to serotonin levels, depending on what material you read or what doctor you talk to. This medicine is working on the assumption that some types of migraines are caused by glyceryl trinitrate nitrate (GTN) — especially induced migraines for the purposes of clinical studies on migraine medicines.
What is GTN? It’s a medicine that is more commonly used for treating angina, heart failure and pulmonary edema. You probably know it best as “Nitro”. It’s been around since 1870. As a medicine, it has to undergo a process called “denitration” to remove nitric acid.
As a side effect, it can induce migraines without auras. What bliss.
Study Specs
This wasn’t a huge study — only on about 45 human guinea pigs that have chronic migraines and 19 controls (lucky bastards that don’t get migraines). All test subjects were hooked up to EEG machines to check on brainwave patterns (a good indication of the electrical activity of the brain). Special notes were taken during the migraine and thirty minutes after getting the valproate sodium shot, when the effects were being felt.
Indications look good, and there have (so far) not been any reported side effects. Kinda makes you wonder what else they put in that needle besides 300 mg of valproate sodium? (Sorry — couldn’t resist.)
What Does This Mean?
Stay away from GTN, that’s for sure.
This isn’t an entirely new drug — valproaic sodium has been used for treating eplieptic seizures for years. However, that’s all it is approved for. There is an oral version for seizures, but so far the oral version hasn’t been tested for migraine treatment. Keep in mind that the FDA has just issued warnings about the mental and emotional side effects of anti-convulsants.
If valproic acid sounds familiar, that’s because the brand name anti-convulsant Stavzor (which is basically the same thing) is currently getting approval for migraine treatment in the US.
It is expected to be legally available in America for migraine treatment in July of this year. This European study looks promising for Stavzor. However, it’s not currently approved for migraine treatment in Europe. Not yet, anyway.
Now I have a migraine coming on. Until tomorrow, gentle readers.
I can’t remember if I ever mentioned this experimental abortive drug for migraines on this blog before now. That’s what enough migraines and blog posts will do to you over time, make your memory a little wacky.
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