Dealing With Headaches

A recent study in The Cohrane Library published in the Land of Oz (Australia, of course) concludes that oxygen therapy may significantly help those suffering from cluster headaches or migraines. 210 human guinea pigs volunteered to participate in nine small studies around Oz in order to compare treatments. Cluster headeadche patients, in partuicular, did much better than placebos after 15 minutes of breathing in an oxygen chamber.

Normobaric and Hyperbaric Therapy

There are two kinds of oxygen therapies. Sadly, just breathing in and out like usual doesn’t count. Anyway, normobaric oxygen therapy refers to breathing pure oxygen from an oxygen tank. Buy hyperbaric oxygen therapy (the one considered so promising) involves going in a chamber and breathing pure oxygen. Why the chamber? The chamber is put under pressure.

No, I have no idea what this means, either.

Which Leads Us To The Problem

Finding an oxygen chamber is just about as hard as trying to comprehend oxygen therapy. Critics of the Oz study point out that the migraine or cluster headache might even be over before the patient can begin snorting the pure oxygen. Also, oxygen tanks are highly flammable (not that this hasn’t stopped us from driving cars). However, this could be a first step in finding a far more practical solution.

Meanwhile, keep on taking your usual medicine.

It’s a beautiful day in the Pain-er-hood
A beautiful day for a neighbor… Howdy, neighbor! Hope you are having a great day. No? You say your life sucks because of acute migraines, which really aren’t so cute? Well, follow me to the Land of Make Believe, otherwise known as the wacky world of Phase I Clinical Test trials for new drugs, where anything can happen and usually does.

Can You Say ‘Transdermal’? Sure You Can!

One of the suppossed breakthroughs in modern medicine is the creation of the transdermal patch. That’s one of those white bandage doo-hickeys you tape to your body and then absorb the medicine bit by bit through your skin. This really isn’t much different than the medicinal poltices or herbal compresses native healers have used for thousands of years. However, it wasn’t hip until the success (read=lots of money made) on the nicotene patch.

Why am I not keen on transdermal patches? Because I have realtives who can’t have them because for some strange reason their bodies soak up all of the goodies in the patch IMMEDIATELY. This has lead to some very sick relatives. However, those that used the nictoene patch when they tried to quit smoking were pretty happy until they found out why they were so happy.

The Latest Future Star

NP101 is the trail name of the transdermal patch for acute migraines that has done well so far. It is put out by NuPathe, Inc, a very small pharmaceutical company reported to be “privately held” (sounds painful.) The patch is a combination of sumatriptan (the active medicine in Imitrex) and “NuPathe’s SmartRelief™ proprietary iontophoretic transdermal technology”. (No, I don’t know what that means, either, but it sure sounds impressive, doesn’t it?)

The Nitty Gritty

NP101 was tested against Imitrex nose spray, tablet and injections. There were 23 human guinea pigs descibed as “healthy”. I assume that means the subjects were not prone to migraines if they were “healthy” and that the migraines were chemically induced. I could not find details of that fact on the Internet or in NuPathe’s press release.

The big hope is that the patch can give you the same relief as with triptans, but without the wacky side effects. It didn’t give any serious side-effects to the 23 volunteers except swelling of the skin at the patch site. Although some reports say this patch will be availbale in a year, odds are with the way Phase II and Phase III Trials have gone for other drugs recently, that it will be at least two years.

Whoops. That’s all the time we have for this episode, boys and girls. Time to go back to real world where all your dreams are clouded by a haze of blinding migraine pain and splintering dry heaves. Bye for now!

People with migraines and chronic headaches go through a lot of worries, one of which is that they will get Alzheimer’s. We’re not alone in this worry. A recent study from the MetLife foundation showed that more Americans are afraid of getting Alzheimer’s than they are of getting heart disease or diabetes. And we are far more prone to getting heart disease or diabetes than we are of getting Alzheiomer’s.

Yet, out of all the diseases you could be dealt with, Alzheimer’s seems to be the big one that we all fear. And will continue to do so.

The Bad News

A very promising drug, Flurizan, that passed one clinical trial has failed it’s latest one. It included volunteers from all over the nation, including those in the Greater Philadelphia area (mine). Today, Myriad Genetics Inc issued a rather terse statement that they found Flurizan to show no significant help to Alzheimer’s patients.

This is the second Alzheimer’s drug to fail in clinical trials this month. The other one was made by Wyeth with the eye-blinking name of Bapineuzumab. (Gezundheight).

The Good News

The good news is that two evil Big Pharma companies gained some karma points by being honest that a drug didn’t work BEFORE the drug was sold. You don’t hear about that every day. Usually, they never admit when a drug doesn’t work. They hint that the drug does work in some way but is not being developed due to financial reasons.

What Have We Learned?

Never trademark your experimental drug until its passed its Phase 3 Clinical Trial.

Oh, for Pete’s sake. Was it a slow news day in the non-profit community or what? We have war, famine, the ecological crisis, natural disasters like Paris Hilton and all the Center for Enviornmantal Health and Justice (CHEJ) can point the middle finger at is PVC shower curtains. On Friday June 13, CHEJ put out an a press release that calls PVC shower curtains toxic. I’ve been dying to get my mits wrapped around this press release, but first 451 Press went down and then my Internet went down. So, stand back, this has been brewing all damn weekend.

Anyway

Granted, new shower curtains suck. They have that new shower curtain smell which I’ve noted has never been duplicated in a line of perfume or as a special aromatherapy candle scent. Strong smells can certainly trigger bad headaches.

CHEJ (which I assume is pronounced either “cheese” or “chez”) claim that new shower smell can kill you…eventually. This is because, in 28 days since the bag is opened, the PVC released 108 different VOCs (volitale organic compunds) which are generally bad news and do every bad thing you have ever imagined (including headaches) and things that only Stephen King could imagine.

However, your shower water also releases VOCs. Are you going to stop taking a shower? And, quite frankly, how much time DO you spend in the bathroom?

Should We Ban Shower Curtains?

Great, that’s all we need — a black market for new shower curtains. “Psst, lady — you lookin’ for a new shower curtain? I got florals, tropicals and pastels.”

First we can’t feed ourselves right and they have a trans fat ban. Then, we can’t ride in a moving vehicle right and have to strap our kids into incredibly expensive car seats. Now, they’re trying to get us in the shower. Hey, there’s naked people in here — go get your bans somewhere else!

Folks, how STUPID do we have to be that we need a ban or a warning label on common household items? (Don’t answer that). If you know the new shower curtain is gonna stink, open it up and stick it in a room where no one spends a lot time in (like a basement or attic) and let it air out. Either that, or stick it outside for a couple of days. THEN install it in the bathroom.

Imagine a world without new shower curtains. Remember, folks, extinct is forever. Save the new shower curtains!

Ahhh…I feel so much better now. Was it good for you, too?

A study from Drexel University doctors have come out claiming that those with PSTD (more commonly known as Post Traumatic Stress Disorder — once known as “shell shock”) most likely get migraines. This is not really a surprise for migraineurs. After all, going through a migraine is a pretty traumatic experience in an of itself. Like most current medical studies, this one was done in respose to an earlier study.

What Is PTSD?

It needs to get back to being called “shell shock”, that’s what it means (as George Carlin pointed out years ago). Ever see a Mack truck come at you and just miss sending you to The Wild Blue Yonder? The response you feel after that is shell shock, or PTSD. There is some talk that shell shock is only what immediately happens after the scary event and PSTD are the long-term effects. For some of us, that’s pretty much the same thing. There’s probably a lot of doctors who’ll disagree with me and feel free to do so. I’m not a doctor. But I have been diagnosed as having major depression, migraines and PTSD.

After living my life, you’d have shell shock, too, as opposed to PTSD.

The practical upshot is that with both migraines and PSTD, legal acess to powerful prescription drugs is involved. Unlike many people with migraines, though, PSTD can lessen it’s grip on you over time, while the migraines tend to hang around.

To qualify migraineurs for this study as having PTSD, they had to have at least one traumatic event happen to them. This could include surviving a natural disater, seeing a friend get killed, or being forced to listen to Justin Timberlake’s “SexyBack” for the millionth time. People with chronic migraines had higher percentages of having shell shock or PTSD than people who only get migraines once in a while (called episodic migraines. Oh, how I wish to merely have episodic migraines. Oh, God, if You could do anything, just boot me from the chronic migraine list to the episodic migraine list.)

The study also notes that people with clinical or major depression are also more prone to getting chronic migraines.

Ooo, don’t you just wish you were me? Like me, you could have a happy Trinity living in your head — major depression, chronic migraines and Post Traumatic Stress Disorder.

I’m not entirely sure that announcing the findings of this study was such a wise idea. We migraineurs are already depressed. Don’t give us even more misery to look forward to.

I only have one relative that I know of who is left handed. There might be others, but they’ve kept really quiet about it. My Aunt Marjorie had to endure a lot of teasing growing up — and, quite frankly, at over blah-de-blah years of age, she probably still gets her fair share of it. Unfortunately, she has more than her fair share of hardships in life. However, she does not get migraines.

Which somewhat contradicts the recent study between migraines and left-handnessness that recently came out from a group of German scientists. They only polled 100 Europeans and clearly had no contact whatsoever with my Aunt Marjorie.

Although the study ultimately was inconclusive on whether lefties have MORE migraines, but it suggests that being left-handed makes you more prone to migraines. As ususal for any kind of medical study, they have called for more medical studies to be done. I guess this keeps the medical studies industry going. (And can I buy stock in this group that keeps medical studies going on forever?)

About Left Handedness

Lefties are generally male (according to Wikipedia — not according to my family). There are about as many people who thinks left-handedness is a sign of genius, while just as many other people say “Whaddya, NUTS?” Famous left-handers include Sir Paul McCartney, Freddie Mercury and my Aunt Marjorie. Animals can also show signs of being right pawed (hooved, finned, whatever) or left pawed. For example, anyone who has ridden horses a lot will know horses have a tendency to behave better favoring one side than the other.

We could do a very unscientific study here and ask you, Gentle Readers, to answer the following as honestly as you possibly can on a May afternoon:

• Are you left sided, right sided or ambidextorous?
• Do you have migraines?
• Are you related to me?

I’m not sure how the scientific community will handle the results of our little study. Probably by calling for more studies to be done.

It’s not available yet and won’t be for years, but a promising new nasal spray is being developed by ROXRO Pharma (you think manybe a dog named the company?) This intranasal treatment, known as ROX-828, shoots a fine spray of NSAID ketorolac up your nose to be immediately absorbed into your system. It has produced promising results in a European clinical trial.

Why A Nasal Spray?

There are already ketorolac pills available, but they have whopping side effects. This is one of the most powerful NSAIDs legally available and is only advised for short term use. It’s usually given for post-operative pain, for example. It works on reducing hormones in your body that are though to contribute to pain making.

With a nasal spray, it’s hoped that not only will a migraine in progress be stopped, but that there will be less severe side effects. These stests are showing that a nasal spray can administer the medicine as quickly as a needle injection. So far, the studies are showing that the nasal spray works to alleviate migraine pain within two hours of spraying.

ROXRO is also working on a different formulation called ROX-888 which is has just completed its Pahase 3 Clinical trial in the US. The results are being compiled and it’s probably going to be a while to interpet them accurractely. ROXRO hopes to submit a “new drug” application to the FDA later this year.

And then the wait continues.

I could not find out how much this stuff is planning to cost. I expect it’ll be a whopper, even in comparison to preventative migraine medicines like Imitrex.

You know how in the conclusions of these clinical trials or medical studies, there is a call for more studies? Well, this is one of the results of a follow up study about the relationship between a woman’s migraines and her heart. All the gory details are in this previous post. Which gives us all even more proof for what we gals already know — it sucks to be us.

What’s This Study Say, Then?

3568 women with migraines (I wouldn’t like to be in that room) took part in the twelve year study, a part of an overall massive Women’s Health Study (say it with trumpets). Although only 3568 women migraineuers took part, over 27,000 American women health professionals did as well. (That’s about nine thousand doctors looking anxiously at each patient…in a way). During the study, some cardiovascular whoopsies happened to some of the volunteers:

• 706 cerebrovascular events (a fancy way of saying “stroke”)
• 305 heart attacks
• 310 ischemic strokes(where specifically an artery to the brain gets blocked. Not nice.)

The women who seemed to be the most prone to these cardiovascular problesm were woemen who had at least one migraine per week. (Damn — I’m screwed). And, as usual, the study recommend sthat more studies need to be done.

Although migraines are bad for my heart, I’ll take them ove any of my ex-boyfriends any day. They REALLY destroyed my heart. At least with migraines, I have some chance of getting high quality drugs after the heart attack. Hmmm, at least that’s something to look forward to.

It’s no surprise that often migrainers become extremely sensitive to sounds, light and sometimes tastes during migraine attacks. I had suspected that migrainers could get super sensitive to touch as well, because of my Mom’s unusual comment when she has a migraine that “My hair hurts.”

Well, Mom, You’re Not Alone

A recent study published in the April 22, 2008 issue of Nuerology found that migraineurs have yet another item to add onto their misery list. 16,573 people participated in the massive study, of which over 11,000 were diagnosed migraineurs, and nearly 1500 were “probable migrainerus” (ie — they hadn’t gone to the doctor yet, but display all the symptoms of migraines) and 3345 people just had “headaches”. About 68% of the lot had some skins owies when having a migraine or headache.

The practical upshot of all of this is that migrainerurs often find normal tasks like wearing jewelry, brushing their hair or rubbing your head as “excruciating”. The technical name for this sudden extreme skin sensitivity is allodynia. This was seen to happen to those not only with chronic head pains but also to those who fell into these categories:

• Women diagnosed with migraines
• Obese people diagnosed with migraines
• People diagnosed with the double whammy of migraines and depression

So?

One of the good points of this study is that it vindicates my Mom’s statement that when she had a migraine “her hair hurts”. We teased her about that when I was a kid, and do I feel guilty about that now. Perhaps migraineurs with skin sensitivity will be taken seriously now by both doctors and family members. As to treatment for this symptom, no recommendations were made other than:

“More importantly, this condition may be a risk factor for migraine progression, where individuals have migraines on more days than not. Identifying risk factors for progression is a very important public health priority. For example, it may be that individuals with allodynia should be more aggressively treated in order to prevent migraine progression, as well as to decrease this sensitivity on the skin.”

Obviously, more studies need to be done, both to determine relief for the symtom and to see if skin sensitivity is a reliable factor in determining whether migraine disease is getting worse in an individual.

Off to take some Excedrin.

The National Headache Foundation and the American Academy of Neurology teamed up for a honkin’ big study of 24,000 people on which drugs might make a person more prone to getting migraines. The key thing to remember about this study is that it looked at the OVERUSE of drugs (which can happen even to the best of us, admit it), and not drugs that are used as directed or only used briefly.

The study also noted that overuse of these medications could give someone with the occassional migraine or headache a chronic migraine problem.

The No-No Drugs

Well, no big surprise. The drugs that can increase your chance of migraines are drugs that you shouldn’t be overusing anyway. They include:

• Codeine, or even medicines including codeine like Co-Tylenol
• Oxycodone (my Mom takes this but she has spinal stenosis and so I think she’s welcome to get all she can take)
• OxyContin (the brand name of oxycondone)
• Any other opiate (including opium — sorry, but some people need practical advice)
• Other barbituates, (of which Oxycodone is a prominant member of)

Drugs That Don’t

Before we get onto this list, let me tell you that you shouldn’t overuse any drug. That won’t be a tactic that King Solomon would exactly approve of. But, if you are going to risk you life by overiusing some drugs, at these won’t give you any more migraines than you are already getting. Bleeding ulcers, maybe, but not migraines. These include:

• NSAIDs such as ibuprofen, naxoproxen and that crazy little thing called aspirin
• Triptans, including Imitrex
• Marijuana (I’m joking — this was never mentioned in the entire study, but it does make you wonder)

The study also didn’t mention anything about rebound headaches, which happen often when the body has become dependent on high does of painkiller and gives you a nasty headache in order to force you to take the drug it wants.

The moral of the story: We need better drugs that makes us complacent to the asurdity of life that doesn’t give us any more headaches than we already get from Big Pharma, inflation, global warming, governments that don;t do a damn thing and the Geicko Gecko. Thank you sir, may I have another?

No, seriously, only take medication when you absolutely need to and follow the directions. And keep your drugs locked away from kids.

I’ve never been a big fan of botox (”Don’t Believe the Botox Hype”.) The “bo” part of the name stands for botulinium toxin A. That means it’s in the botulism family. I’m an even less of a fan of botulism. Why would you risk sticking botulism in your face? Hey, I’ve never understood why “American Idol” is so popular, and that’s popular, too. Besides smoothing out your face, botox was rumored in to help relieve chronic headaches (it doesn’t).

So, as a reminder — botox will not relieve your chronic headache or migraine. And, a recently released study shows that botox can sink into your brain.

As another reminder, your brain doesn’t need smoothing out. It really needs all of those wrinkles.

What About This New Study?

Sadly, the study was done on rats instead of people. I’ve never been bitten by a rat, but I have been bitten by people, so I am admittedly predjudiced about being pro-rat. They were botox injections into the whisker area (that’s gotta hurt!) Thtree days later, the rats were killed and their brains opened up, which showed traces of the botox in the brain tissue and brain stem (which makes you wonder what these scientists do for fun.)

This is a preliminary study, so nothing’s conclusive (except if you’re a rat in a medical lab, you’re screwed). There is a call for similar studies to be done on monkeys (oh, joy.)

Wouldn’t it be easier to not just the damn botox in the first place?

Substitutions for Experimental Animals

Personally, I think we should stop all animal experimnentation. It’s expensive, it’s cruel and often doesn’t relate to what human bodies go through. What about all these criminals sitting on death row? What about that guy sitting for life at our expense who claimed to have something to do with 9/11? I say botox HIS whisker area and then dissect his brain three days later. We have all these prisoners who hate themselves and are a drain on society. Bu giving them a chance at medical becoming human lab rats, then they can feel that they are doing something quasi-heroic.

Surprisingly, I get a lot of strange looks when I bring this subject up.

But seriously, we could also do computer models and in vitro (in test tube) experiments instead of ripping open animals by the millions.

Remember — botox = death.

On that happy note, have a great weekend.

I don’t know about you, but I’m getting confused over what migraine and chronic headache medicines are currently in development (whether in clinical trails, experiments for clinical trials or, like with Stavzor, received FDA approval and will be released in the summer). And I can’t be the only one. (Alright, maybe I AM the only one, but this is my blog and I can prentend omniscience if I want to. So there. Nyah nyah nyah.)

I did try to put all previous posts about migraine drugs in development into a new category (see right sidebar), but for some reason the Category feature on WordPress is a wee bit cranky this week, so I better not press my luck.

Anyway, here’s a little list of links of previous posts about the Great Medicinal Hope to come, later rather than sooner. This is not a comprehensive list of ALL drugs for migraines or chronic headaches in development around the world. I couldn’t find that list. And I have a feeling if I did, I’d be shot. But there is a list for all of the current clincial trials in America for headaches and migraines, put together at My Migraine Connection.

Let’s get on with the list, shall we? And have a pain free weekend.

Zolmitriptan Shown Promising for Adolescent Migraine Relief
So Far So Good With Tezampenel Second Clinical Trial
Take Two Dissolvable Aspirin And Call Me In the Morning
ProEthic Pharmecueticals Hopes to Release Migraine Drug in 2008
AZ-104 Phase 2a Clinical Trial Closed
Stavzor for Migraines Gets FDAs OK
POZEN Poses to Make New Migraine Drug
Meet Experimental Drug CGRP for Migraines

I can’t remember if I ever mentioned this experimental abortive drug for migraines on this blog before now. That’s what enough migraines and blog posts will do to you over time, make your memory a little wacky.

Anyway, the drug in development that is getting a lot of promising buzz is called (wait for it) calcitonin gene-related peptide. Mercifully, it’s usually known as CGRP for sanity’s sake. This is a neropeptide (a little chemical ding-hooey in the brain that helps gets things done in the body) activated by a protein called RAMP1. (Let’s not go into what RAMP1 is short for.) It seems these two brain chemicals are great mates — if one gets excited, so does the other. The theory is that these two could be responsible for migraine pain and possibly for the pain of cluster headaches.

You Can’t Get It Yet

CGRP for migraines and cluster headaches is still in the clinical trial stage. Giant Pharma company Merck currently has a hold of it and calling it MK-0974. Although also known as CGRP in some media publications, MK-0974 actually BLOCKS CGRP from getting excited. It is currently thought that MK-0974 will have less side effects than current drugs like triptans.

MK-0974 is currently in the Clinical Trial Stage III phase and not looking for any more human guinea-pigs. The experimental drug is currently just be checked for migraines. Presumably, if they get the OK to market it for migraines, then they can do the whole clinical trial merry-go-round again for cluster headaches. This means Merck gets to hold on to the patent for another decade or so before it would be required to go generic.

Practical Upshot

Where there’s life, there’s hope. There is something waiting in the wings in a lab somewhere. In the meantime, work with your doctor to help tame your pain. That’s pretty much what most of the rest of the posts on this blog is about.

Nope this helps….whoops! That’s a typo!!! HOPE this helps. (Arrghhh)

Marijuana (cannibis) is an extrememly effective painkiller, although sometimes it’s effective in that it knocks you unconscious. When I lived in England, it was far easier to get street marijuana for a toothache than to get a dentist appoinment. Keep in mind that the cannibis laws are a lot less harsh in England than in America, especially for posession of a very small quantity. I self medicated for toothache, insomnia and migraine when I was in England.

I do not personally recommend marijuana for migraines. With toothaches and insomnia, it worked pretty well, provided that was the only reason I took it. My body would react in a very annoyed fashion on the few occassions I took cannibis “recreationally”. In fact, my migraines would intensify when I regained consciousness.

Self-Medication Is Dangerous

Taking marijuana for migraines is a bit like using a cannon to get somebody’s attention. This is powerful, powerful stuff that needs to be treated with the greatest of respect and NEVER make any assumptions about what it is going to do to you. My body happens to react badly to cannibis (I suddenly loose control of my bowels, among other things). I can’t be the only human being out there that this happens to (”Yes, Rena — just you!”)

Cannibis is one of the easiest drugs that you can attain because there are so many people offering to sell it. One of the reasons I’m writing about marijuana for migraines is that I once had a seller insist that cannibis was the best cure for migraines ever. His argument was really convincing, partially because when I have migraines, I feel pretty desperate and am willing to grasp at any life preserver.

Don’t be that desperate. Although getting cannibis is relatively easy, getting a consistent quality of cannibis is the big danger. And not all cannibis is alike. Some kinds not only taste foul (no matter how you administer it), but can have far more powerful and debilitating side effects.

And, in the United States, there is that tiny problem of cannibis being illegal to possess. In Canada, it’s a different story, but you ned a prescription. However, it’s INCREDIBLY expensive.

Whatever Happened To the FDA Study?

There was a lot of hoopla in 1999 about an FDA approved study about marijuana and migraines. After eight years, I haven’t been able to find any updates on this study. I’m asumming it’s still going on, but haven’t been able to discover anything definate.

If you are considering marijuana for migraines, no one’s going to blame you for being curious. But talk seriously to your doctor before you do any potentially dangerous experimentation. Cannibis will not make you evil. Since it’s such a misunderstood plant, not many people know what it can and can’t do (unlike a drug like aspirin, which is predictable). You could wind up harming yourself rather than helping yourself.

At least, that’s the conclusion drawn in the latest issue of Nuerology that comes out today. It was hoped that oxcarbazepine (which is officially classified as an anti-epileptic drug and sold under the brand Trileptol) could prevent migraines. The bad news is that oxycarbazepine is no good for migraine prevention. The good news is that it still works well for epiliptics. Unfortunately, this not a blog about epliepsy.

How’d They Come To This Conclusion?

“They” in this case is the fine researchers at Thomas Jefferson University in Philadelphia. (Can you tell that I come from the Greater Philly area?) The study took about five months with human volunteers from clinics all over the country. All told, 170 human guinea pigs took part, of which I am grateful, because no real guinea pigs were harmed in this particular study.

All of the human guinea pigs had at least three to nine migraine attacks a month. Half took a placebo while half took the oxcarbazepine. The results? There was no difference whatsoever between those that took the placebo and those that took the oxcarbazepine.

Why Did They Think It Could Work In The First Place?

Drugs for epilepsy have been able to help prevent migraines in a lot of people in the past. Unfortunatley, this one doesn’t join the ranks. There was a particular hope for oxcarbazepine to be a migraine preventative as it has very mild side effects.

The epliepsy drugs that do help prevent migraines (and have side effects harder on the body) are:

• Topiramate (the ever popular Topamax)
• Divalproex
• Gabapentin (brand name Nuerontin)

Ironically, this study was funded by the very makers of oxcarbazepine, Novartis Pharmaceuticals. Hmmm, I guess they didn’t pay the researchers enough (Cheap joke — sorrry!)

Here’s a quick reminder of the FDA’s recent warning about all anti-convulsants or medicines for elipetics (including Topamax and Nuerontin).

Hope this helps.